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Biochemistry Proteins and Amino Acids ba425241

Melatonin is synthesized from

A
Histidine
B
Methionine
C
Tryptophan
D
Phenylalanine
High-Yield Explanation
Ans. c (Tryptophan). (Ref. Harper, Biochemistry, 25th /pg.355)AMINOACID DERIVATIVESPhenylalanine:# Phenylalanine >> tyrosine >> dopa >> norepinephrine >> epinephrine# Phenylalanine >> tyrosine >> dopa >> dopamine >> melanin2# Phenylalanine >> tyrosine >> thyroxineTryptophan# Niacin# Serotonin# Melatonin2Histidine# Histidine -Histamine (by decarboxylation)Glycine# Porphyrin and haeme# Purines# Creatine (totally madeup of glycine + arginine + methionine; mnemonic--GAM)# Glutathione (totally made up of glycine + cystine+ glutamate; mnemonic--GCG)Arginine# Carnitine# UreaMethionine# Choline

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