A 43 year old lady presents with a 5 cm lump in right breast with a 3 cm node in the supraclavicular fossa. To which of the following TNM stage does she belongs to as per the latest AJCC staging system?
High-Yield Explanation
According to AJCC staging system for breast cancer 2003, tumor size more than 5cm in the greatest dimension falls under T3 and N3 indicates involvement of more than 10 axillary nodes, or infraclavicular nodes, or clinically + internal mammary nodes, with + axillary nodes or ipsilateral supraclavicular nodes. Any tumor size plus N3 belong to stage IIIc breast cancer. The new criteria for breast cancer TNM staging have been implemented by AJCC since January 2003. The most impoant prognostic factor and staging criteria is the lymph node status. Sentinel node biopsy provides more accurate evaluation of one or several target nodes. Ref: Modern Surgical Care: Physiologic Foundations and Clinical Applications edited by Thomas A. Miller page 1060.