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Biochemistry Glycogen Metabolism and Glycogen Storage ba025a31

Which of the following enzyme is absent in muscle?

A
Glucose-1-phosphatase
B
Glucose 6 phosphatase
C
Glycogen phosphorylase
D
Thiophorase
High-Yield Explanation
Ref: Harper's Illustrated Biochemistry, 27th edition and Lippincott !s Biochemistry, 3rd editionExplanation:FATE OF MUSCLE GLYCOGENIn muscle, enzyme Glucose - 6- phosphatase is absent.This enzyme catalyzes the final step of glycogenolysis.Hence muscle glycogenolysis does not contribute to blood glucose directly.Glycogen of muscle can only be converted upto glucose - 6 - phosphate as muscle lacks glucose - 6 - phosphatase.Glucose - 6 - phosphate cannot cross the plasma membrane and enters the glycolytic cycle, where it is converted into lactic acid.This lactic acid cross the plasma membrane and reaches liver to form glucose

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