Febuxostat:

Ans. (a) Anti-gout and Xanthine Oxidase inhibitorRef. Katzung's Pharmacology 10th ed. Ch 36* Febuxostat is a non-purine inhibitor of xanthine oxidase and thereby reduces the formation of xanthine and uric acid and is useful in management of gout.* It is 80% absorbed following oral administration and extensively metabolized in the liver.* All of the drug and its metabolites appear in the urine although less than 5% appears as unchanged drug. Because it is highly metabolized to inactive metabolites, no dosage adjustment is necessary for patients with renal impairment.