Which type of amyloidosis is caused by mutations in transthyretin gene?

Transthyretin (TTR) is a normal serum protein that binds and transpos thyroxine and retinol. Several distinct mutant forms of TTR (and its fragments) are deposited in a group of genetically determined disorders referred to as familial amyloid polyneuropathies. Normal TTR is also deposited (Due to overproduction) in the hea of aged individuals (senile systemic amyloidosis).