Berry aneurysm - Defect lies in

*In berry aneurysms basic abnormality lies is the congenital deficiency of the tunica media(elastic tissue)in the aerial wall. Intimomedial mucoid degeneration (IMMD) is a rare vascular disorder characterised by the deposition of mucin in the intima and media, which leads to elastic tissue degeneration and aneurysm formation of the aerial wall.Although the condition was initially thought to involve only the aoa, subsequent publications have repoed IMMD to affect the major branches of the aoa, as well as smaller vessels such as the coronary and brachial aeries.The aneurysms in IMMD usually have a saccular or fusiform morphology and cause symptoms related to the location of the aneurysm. Surgery is often complicated by a bleeding diathesis distinct from disseminated intravascular coagulation (DIC), but which resolves after surgical treatment of the diseased vessel. Meticulous surgical technique is of paramount impoance. Peri-operatively, the coagulation profile and platelet function should be carefully monitored and diligently corrected Ref Harrison20th edition pg 2456