Marker of Melanoma: (E. REPEAT 2012)

Ref: Rook 's Textbook of Dermatology and Robbins Pathologic Basis of Disease, Bth edition. Pages 1171-5Explanation:MELANOCYTE DIFFERENTIATION MARKERSSI 00.Gpl00/HMB-45 (homatropine methylbromide 45).Typrosinase.MART-1 /Melon-A.IIMW_MA A.Proliferation markers (proliferating cell nuclear antigen. Ki67).MIA (Melanoma inhibitory activity).Micropthalmia Transcription Factor (MiTF).SHH) is less specific, but highly sensitive and therefore is usually used in combination with at least one of the others.OTHER MARKERSKeratin 20 (Ck20)Type I cytokeratin.Major cellular protein of mature enterocytes and goblet cells.Found in the gastric and intestinal mucosa.Used to identify a range of adenocarcinomata arising from epithelia.Present in:o Colorectal cancero Transitional cell carcinomaso Merkel cell carcinoma.Absent in:o Lung cancero Prostate cancero Non-mucinousovarian cancer.VimentinType III intermediate filament (IF) protein.Expressed in mesenchymal cells.Used as a sarcoma tumor marker to identify mesenchyme.Used in:o Colon cancero Esophageal adenocarcinomao Intestinal type gastric cancer.