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Pathology General b8fa1550

The expression of JAK2 mutation is seen in all conditions, EXCEPT:

A
Chronic eosinophilic leukemia
B
Primary myelofibrosis
C
Polycythemia vera
D
Essential thrombocytosis
High-Yield Explanation
Polycythemia vera (PV), Primary myelofibrosis (PMF) and Essential thrombocytosis (ET) are characterized by expression of a JAK2 mutation, V617F. It causes constitutive activation of tyrosine kinase. PV, PMF, and ET are transformed into acute leukemia very rarely. Ref: Harrison, Edition-18, Page-898

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