Insulin synthesis is stimulated by glucose levels above

Glucose levels >70 mg/dL stimulate insulin synthesis, primarily by enhancing protein translation and processing.Glucose stimulation of insulin secretion begins with its transpo into the beta cell by a facilitative glucose transpoer. Glucose phosphorylation by glucokinase is the rate-limiting step that controls glucose-regulated insulin secretion.Ref: Harrison 19e pg: 2402