Swan neck deformity is seen in: March 2013 (a, c, e)

Ans. B i.e. Rheumatoid ahritis Rheumatoid ahritis RA is a disease of: Synovium/ synol membrane RA stas in: Synovium Body tissue mostly affected in RA: Synovium Characteristic feature: - Persistent inflammatory synovitis, - Peripheral joint, - Symmetrical distribution Causes: - Immunological, - Familial, - Infective (implicated) Mostly affects: Females (three times) Earliest lesion in rheumatoid synovitis: - Microvascular injury, - Increase in number of synol lining cells Joints characteristically involved in RA: - MCP, - PIP (symmetric ahritis) Boutonniere deformity: - Flexion contracture of the PIP - Extension of DIP Criteria for diagnosis: Any 4 criteria must be present Pathognomic feature: Rheumatoid nodule Extra-aicular manifestations are seen in: Individuals with high titres of RF (autoantibodies to the Fc component of IgG)