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Microbiology Immunology b8582b8d

A 25-year-old man is exposed to Ascaris but does not develop clinical signs of infection. Which of the following mechanisms is likely to be responsible for his resistance to infection?

A
Antibody mediated destruction of worm infected host cells
B
CTL induced apoptosis of worm infected host cells
C
Complement mediated lysis of worm attached to host tissues
D
IgE mediated type I hypersensitivity disrupting worm attachment
High-Yield Explanation
Ans. (d)Local inflammatory responses such as that induced by IgE can inhibit attachment of roundworms to the intestinal wall. Ascaris is a large worm and is not damaged by antibodies directed at it or by complement, CTLs or phagocytes.

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