All of the following statements concerning CO2 transpo are TRUE, EXCEPT:

The solubility of CO2 in blood is twenty times that of O2, and thus a small but considerable poion of CO2 is dissolved in blood (5%). The bulk of CO2 transpo involves its reversible combination with water. This occurs rapidly enough because of the action of carbonic anhydrase, an enzyme located inside RBCs. As bicarbonate ion diffuses out of RBCs, chloride ions diffuse in according to Gibbs-Donnan equilibrium. Combination of CO2 with amine groups, especially those of hemoglobin, also accounts for a significant poion of CO2 transpo (5%). Ref: Barrett K.E., Barman S.M., Boitano S., Brooks H.L. (2012). Chapter 35. Gas Transpo & pH. In K.E. Barrett, S.M. Barman, S. Boitano, H.L. Brooks (Eds),Ganong's Review of Medical Physiology, 24e.