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Medicine General b741c04f

Venoocclusive disease of the liver is caused by:

A
Cyclophosphamide
B
Melphalan
C
Both
D
None
High-Yield Explanation
Potential target for sinusoidal lining cells; when these are injured, such as by high-dose chemotherapeutic agents (e.g., cyclophosphamide, melphalan, busulfan) administered prior to bone marrow transplantation, venoocclusive disease can result. Reference: Harrisons Principles of Internal Medicine, 18th Edition, Page 2560

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