Type of human papilloma virus associated with cacinoma cervix

Explanation: Juvenile Papillomatosis of the breast ● It is a relatively common benign localised proliferative lesion in the breast. ● It is mainly seen in young women (mean age: 19-23 years) ● Caused by HPV 6 and 11. Clinical presentation ● Patients present with a firmt well-defined, mobile mass often in the periphery of the breast. ● There is usually no nipple discharge. Pathology ● Papillary proliferation of the ductal epithelium which partly fills up smaller ducts causing distension. ● Grossly, well-circumscribed mass containing multiple small cysts (<2 cm) within a dense fibrous stroma (therefore sometimes termed swiss cheese disease by pathologists). ● Lesions can vary in size, usually ranging from 1 to 8 cm. Radiographic features Breast ultrasound ● They can appear as an ill-defined, inhomogenous hypoechoic mass with multiple small (up to 4mm) predominantly peripheral cysts. ● Microcalcifications may be seen at sonography. Mammography ● These lesions are usually negative on mammography. ● Occasionally may show microcalcifications, an asymmetric density or a prominant intraductal pattern.  Galactography ● May show a multiple irregular filling defects within the breasts. Breast MRI Signal characteristics according to one report include ● T1 : hypo-intense lobulated mass ● T2 : may show- presence of multiple small internal cysts, best shown on this sequence and is considered the most specific feature ● T1 C+ (Gd) : may or may not show marked rapid enhancement ● Dynamic sequence: shows a benign enhancement profile. Complications ● Despite being a benign entity, it is considered by some to be a marker for familial breast cancer. ● Approximately /0% develop breast cancer later in life.