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Pathology Pediatrics, environment and nutrition b67f9cfc

Bone affection in scurvy is due to which of the following

A
Poor mineralization of the osteoid tissue
B
Defective osteoid matrix formation
C
Defective calcification in osteoid
D
Increased degradation of osteoid tissue
High-Yield Explanation
The most clearly established function of vitamin C is the activation of prolyl and lysyl hydroxylases from inactive precursors, allowing for hydroxylation of procollagen. Inadequately hydroxylated procollagen cannot acquire a stable helical configuration or be adequately cross-linked, so it is poorly secreted from the fibroblasts. Those molecules that are secreted lack tensile strength, are more soluble, and are more vulnerable to enzymatic degradation.collegen is required for osteoid matrix formation. Reference: Robbins basic pathology, pg no:301

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