Pharmacology General b63f45ba Antiemetic effect of Metoclopromide is mainly due to its action as A 5HT3 antagonist B D2 antagonist C M3 antagonist D 5HT4 agonist High-Yield Explanation Antiemetic effect of Metoclopramide is because of D2 antagonism > 5HT3 antagonism. Prokinetic effect is due to 5HT4 agonism.