Pharmacology General b5d2b60e

What enzyme is inhibited by etoposide ?

Topoisomerase I

Topoismerase II

Dihydrofolate reductase

Dihydro orotate oxidase

High-Yield Explanation

Ans. is 'b' i.e., Topoisomerase(Ref: KDT 7h/e p. 8661)EtoposideSemisynthetic derivative of podophyllotoxin, a plant glycoside'Not a mitotic inhibitor, but arrests cells in the G2 phase and causes DNA breaks by affecting DNA topoisomerase-2 function.

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