In gram negative septicemia, early findings setting before shock of florid is -

The pathophysiology of septic shock is not entirely understood, but it is known that a key role in the development of severe sepsis is played by an immune and coagulation response to an infection. Septic shock involves a widespread inflammatory response that produces a hypermetabolic effect in septic shock |Cardiac output, i Total peripheral resistance Ref Davidson 23rd edition pg 445