All of the following are advantages of transdermal drug delivery systems EXCEPT:

Transdermal route is employed for highly lipid soluble drugs that can traverse intact skin. The size of the pores in transdermal patch is adjusted to produce a uniform and smooth absorption of the drug. This will thus, produce a delayed and smaller peak in the plasma concentration. As the drug is going directly in the bloodstream, first pass metabolism is avoided. Eg : Transdermal patch- Rotigotine is used in Parkinson disease