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Pathology General b5833b59

Gene for Wilm' s tumor is located on-

A
Chromosome 1
B
Chromosome 10
C
Chromosome 11
D
Chromosome 12
High-Yield Explanation
Ans. is 'c' i.e., Chromosome 11 o Mutations of the WT1 gene on chromosome 11 p 13 are observed in approximately 20% of Wilms' tumors. o At least half of the Wilms' tumors with mutations in WTI also carry mutations in CTNNB1, the gene encoding the proto-oncogene beta-catenin.

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