Cause of Clostridium difficle associated diarrhea -

Ans. is 'd'' i.e., Antibiotic use o CDAD is almost exclusively associated with antibiotic use. Ananthanarayan 8th/e p. 263 & 7th/e p. 265]# Pseudomembranous colitis is the advanced form of Clostridium difficile - associated disease (CDAD).Remember:o CDAD is the most commonly diagnosed diarrheal iiiness acquired in the hospital.o C. diffiele is acquired exogenously (not as an endogenous infection), most frequently in the hospital,o C. diffiele is the most common bacterial cause of nosocomial diarrhea,o Diarrhea is the most common symptom of CDAD.Risk factors for Clostridium difficile associated disease (CDAD)o CDAD almost exclusively associated antibiotic used,o The most common antibiotics associated with CDAD are-ClindamycinAmpicillinCephalosporin (mainly cefotaxim, ceftriaxone, cefuroxime and ceftazidime)o Piperacillin/tazobactiim and ticarc i llin/clavlanate less commonly associated with CDAD.o The risk of Clostridium difficile infection is directly proportionate to the hospital stay,o Other risk factors-Old ageGreater severity of underlying illnessGasterointestinal surgeryUsed electrical thermometerCentral tube feedingAntacid useProton pump inhibitorsDiagnosis and Treatment of CDADo Diagnosis# The diagnosis is based on a combination of clinical criteria :Diarrhea (> 3 unformed stools per 24 hrs for > 2 days), with no other recognized cause.plusToxin A or B detected in the stool, toxin - producing C. difficile detected by stool culture, or pseudomembrane seen in the colon.o TreatmentMetronidazole is drug of choiceAlternatives -Vancomycin # Fusidic acidTeicoplanin # BacitracinRemembero Most sensitive test for diagnosis of CDAD-Stool culture for C. difficileo Most specific tests for diagnosis of CDAD-Cell culture cytotoxin test on stool and pseudomembrane seen on colonoscopy or sigmoidoscopy