Radiology General b4dbae53 Central dot sign is seen in - A Caroli's disease B Primary sclerosing cholangitis C Polycystic liver disease D Liver hamartoma High-Yield Explanation Central Dot sign on CT or USG is seen in: Caroli's disease (most common cause); Prebiliary cysts; Obstructive jaundice; and Periportal lymphedema.