Pulseless disease is -

Ans. is 'b' i.e., Takayasu aeritisTakayasu aeritis o Takayasu aeritis is gran u lomatous vasculitis of large and medium aeries.o It is characterized principally by ocular disturbance and marked weakening of pulses in the upper extremities --> Pulseless disease.o It is also characterized by a strong predilection for aoic arch and its branches --> Aoic arch syndrome. o It is more common in Adolescent girls and young women.o Morphological changes in vessel wall are same as in giant cell aeritis.Clinical presentationSymptoms are mainly according to the involved vessel -Subclan aery :o Most commonly involved vesselo Symptoms are - Arm claudication, lower BP and weaker pulse in upper limb then in lower limb, Raynaud's phemomenon. Common carotid -+ Visual disturbances, stroke, TIA, syncope. Abdominal aoa or coeliac aery or superior mesentric aery --> Abdominal pain, nausea, vomiting Renal --> Hypeension, Renal failure Aoic root --> Aoic regurgitation, CHF Veebral Visual disturbances Iliac - Leg claudication Pulmonary --> Pulmonary hypeension, dysnea, chest pain. Coronary Angina, MI Constitutional symptoms --> As with other vasculitis malaise, fatigue, anarexia and weight loss are common. Elevated ESR and Anemia (as with other vasculitis)