Which of the following antihelmintic acts by producing flaccid paralysis of the worm?
High-Yield Explanation
Anti-helminthic drugsAnti-helminthicMechanism of actionParasites susceptibleMebendazole Inhibits polymerization of b-tubulin of susceptible worms - live worms expelled Roundworm, Hookworm, Whipworm, Pinworm, Trichinella spiralis Pyrantel palmate Inhibits cholinesterase in worms - persistent depolarization - spastic paralysis - live worms expelledAscaris, Enterobius, Ancylostoma, Strongyloides Piperazine Hyperpolarization of muscle by GABA agonistic action - flaccid paralysis - live worms expelledAscaris, Enterobius Ivermectin Potentiates glutamate-gated Cl- channel & increases GABA transmission in worms - hyperpolarization and paralysis of worms - dead worms expelledPediculosis, Scabies, Onchocerca, Strongyloides, Ascaris, Cutaneous larva migrans Praziquantel Increased muscular contraction & spastic paralysis of worms - dead worms expelledTrematode, Cestodes Levamisole &Tetramisole Ganglionic stimulation - tonic paralysis - live worms expelledAscaris, Ancylostoma, Strongyloides Diethyl carbamazepine Hyperpolarization of muscles - live worms expelledMicrofilaria of bancrofti, malayi, Loa loa, Onchocerca Niclosamide Inhibits oxidative Phosphorylation in mitochondria Cestodes (Refer: Rang and Dale's Clinical Pharmacology, 7th edition, pg no: 670)