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Surgery Orthopedics b4a1e0f1

Select the type of bone disease with which it is most likely to be associated with genetically determined disorder in the structure or processing of type I collagen (SELECT 1 DISEASE)

A
Osteogenesis imperfecta
B
Osteopetrosis
C
Osteitis fibrosa cystica
D
Osteomalacia
High-Yield Explanation
Osteitis fibrosa cystica is commonly associated with hyperparathyroidism. Hemorrhagic cystic lesions (brown tumors) usually occur in the long bones. Treatment is parathyroidectomy Osteomalacia is defined as a defect in mineralization of adult bone that results from abnormalities in vitamin D metabolism. Treatment generally involves vitamin D supplementation. Osteogenesis imperfecta is a genetically determined disorder in the structure or processing of type I collagen. Treatment is surgical and involves orthoses to prevent fractures and correction of deformities by multiple osteotomies. Osteitis deformans is also known as Paget's disease. Osteopetrosis is a rare skeletal deformity associated with increased density of the bones.

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