Histopathological examination reveals the diagnosis as:
High-Yield Explanation
Characteristic malignant cells of Hodgkin’s diseases are large cells known as Reed–Sternberg (RS) cells (typical and variant), 20–50 micrometers in diameter, abundant, amphophilic, finely granular/homogeneous cytoplasm; two mirror-image nuclei (owl eyes) each with an eosinophilic nucleolus and a thick nuclear membrane (chromatin is distributed at the cell periphery). One or two percent of these malignant cells are admixed within a reactive cell infiltrate composed of variable proportions of lymphocytes, histiocytes, eosinophils, and plasma cells. The Reed–Sternberg cells are identified as large often binucleated cells with prominent nucleoli and an unusual CD15+, CD30+ immunophenotype. In approximately 50% of cases, the Reed–Sternberg cells are infected by the Epstein-Barr virus.
Ref: Shafer’s Ed 7th Pg 187