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Pathology General b478ea52

Histopathological examination reveals the diagnosis as:

A
Ewing sarcoma
B
Kaposi Sarcoma
C
Hodgkin lymphoma
D
Burkitt lymphoma
High-Yield Explanation
Characteristic  malignant  cells  of  Hodgkin’s  diseases  are large  cells  known  as  Reed–Sternberg  (RS)  cells  (typical and  variant),  20–50  micrometers  in  diameter,  abundant, amphophilic, finely granular/homogeneous cytoplasm; two mirror-image nuclei (owl eyes) each with an eosinophilic nucleolus  and  a  thick  nuclear  membrane  (chromatin  is  distributed at the cell periphery). One or two percent  of  these  malignant  cells  are  admixed  within  a  reactive  cell infiltrate composed of variable proportions of lymphocytes,  histiocytes,  eosinophils,  and  plasma  cells.  The  Reed–Sternberg cells are identified as large often binucleated cells with prominent nucleoli and an unusual CD15+, CD30+  immunophenotype.  In  approximately  50%  of  cases,  the Reed–Sternberg cells are infected by the Epstein-Barr virus. Ref: Shafer’s Ed 7th Pg 187

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