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Pharmacology Chemotherapy: General Principles b45d5aab

A patient on treatment for leukemia, develops chest pain, pulmonary infiltrates and pleural effusion. The likely cause is

A
Daunorubicin
B
Hydroxyurea
C
Cytarabine
D
Tretinoin
High-Yield Explanation
Ans. (D) Tretinoin(Ref: Katzung 10th/899; KDT 8th/e p928)Tretinoin causes chest pain, pleuritis, pulmonary infiltrates and pleural effusion. It is a known human teratogen. Daunorubicin and doxorubicin cause cardiotoxicity manifested as arrhythmias and CHF.

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