Treatment of postmenopausal osteoporosis -a) Tamoxifenb) Progesterone c) Estrogend) Alendronatee) Calcitonin

Drug used in osteoporosis Inhibit resorption : -Bisphosphonates, donesumab, cinacalcet, calcitonin, estrogen, SERMS, gallium nitrate. Stimulate formation : -Teriparatide, calcium, calcitriol, fluorides,. Both actions : - Strontium renelate. Drugs decreasing bone resorption initially increase bone mineral density (BMD), but it reaches a plateau in 2-3 yrs because bone formation also decreases. On the other hand, drugs promoting bone formation can increase BMD through the period of treatment. SERMs (selective estrogen receptor modifier) used for osteoporosis → Raloxifene. Bisphosphonates → Etidronate, Pamidronate, Alendronate, Ibandronate, Risedronate, Zolendronate.