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Pharmacology Other topics and Adverse effects b293e9e2

Which of the following statments about the biodisposition of penicillins and cephalosporins is NOT accurate?

A
Oral bioavailability is affected by lability to gastric acid
B
Procaine penicillin G is used intramuscular injection
C
Renal tubular reabsorption of beta-lactams is inhibited by probenecid
D
Nafcillin and ceftriaxone are eliminated minly biliary secretion
High-Yield Explanation
(Ref: KDT 6/e p697) Probenecid inhibits renal tubular secretion of penicillins (not reabsorption) Beta lactams eliminated by biliary route are: - Ampicillin - Nafcillin - Ceftriaxone - Cefoperazone Penicillin G has to be given by i.m. route because it is broken down by gastric acid (decreases oral bioavailability).
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