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Pharmacology A.N.S. b23bbb41

Which of the following drugs has no cycloplegic action?

A
Atropine
B
Cyclopentolate
C
Tropicamide
D
Phenylepherine
High-Yield Explanation
Ans. d (Phenylephrine). (Ref. KD Tripathi, Pharmacology, 4th ed., 88, Basak, Ophthalmology, 2nd ed., 44)# Sympathomimetic mydriatics like atropine (strongest cycloplegic), homatropine, cyclopentolate, tropicamide have cycloplegic action.# Pure a-adrenergic agent - PHENYLEPHRINE (Sympathomimetics) is not cycloplegic.# PILOCARPINE is a local parasympathomimetic ocular hypotensive drug whose mitotic effect is useful in the management of angle closure glaucoma.# It is not a cycloplegic drug.Note: a -adrenergic agents such as phenylephrine or oxymetazoline are generally used topically to alleviate nasal congestion and obstruction.

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