The new terminology for down’s syndrome is ?
High-Yield Explanation
Ref. Oxford textbook of Psychiatry. Page 170
Down’s Syndrome Features
Most common autosomal trisomy
Mental retardation
Short stature
Hypotonia
Depressed nasal bridge, upslanting palpebral fissures, epicanthal fold
Congenital heart defects in approximately 40% of cases
Increased risk of acute lymphoblastic leukemia
Alzheimer disease by fifth or sixth decade (amyloid precursor protein, APP gene on chromosome 21)
Reduced fertility
Risk increases with increased maternal age