Which of the following is seen in Conn's syndrome: September 2007

Ans. B: Hypernatremia Conn's syndrome is primary hyperaldosteronism due to Aldosterone producing adenoma (50%) Clinical presentation Usually occurs between 30 and 60 years Conn's syndrome accounts for 1% of cases of hypeension Hypeension often responds poorly to treatment Biochemically there is usually a hypokalaemic alkalosis (as hypersecretion of aldosterone increases the renal distal tubular exchange of intratubular sodium for secreted potassium and hydrogenions, with progressive depletion of body potassium and development of hypokalemia) Polyuria is due to impairment of urinary concentrating ability. Edema is associated mainly with secondary aldosteronism.