In organophosphorus compound poisoning, organophosphorus compound actions are -

Mechanism of Action Organophosphorus compounds are inhibitors of acetylcholinesterase by phosphorylating the enzyme. Acetyl cholinesterase is required to hydrolyse acetylcholine to choline and acetic acid As a result, there is accumulation of acetylcholine with continued stimulation of local receptors and eventual paralysis of nerve or muscle . Organophosphate intoxication leads to characteristic end-plate abnormalities that reflect the degree of AchE inhibition and increase in Ach concentration at the neuromuscular junction. REF;THE SYNOPSIS OF FORENSIC MEDICINE:KS NARAYANA REDDY;28th EDITION;PAGE NO 291