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Pathology General b14d255d

Which of these genes promote epithelial-mesenchymal transition and are important metastatic genes in epithelial tumors?

A
MYC
B
SNAIL
C
TWIST
D
Both 2 and 3
High-Yield Explanation
Metasis oncogenes are SNAIL and TWIST, which encode transcription factors whose primary function is to promote epithelial-to-mesenchymal transition (EMT).  In EMT, carcinoma cells downregulate certain epithelial markers (e.g., E-cadherin) and upregulate certain mesenchymal markers  (e.g.,  vimentin, smooth muscle actin). EMT has been documented mainly in breast carcinoma. Reference-Robbins BASIC PATHOLOGY 10th edition pg-223

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