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Physiology General physiology b1444c09

All of the following are true about Hepcidin except

A
It is a 25- amino acid peptide secreted by Kupffer cells
B
Decreases duodenal absorption of iron
C
It regulates activity of transpoers DMT - 1 and ferropoin - 1
D
Mice with enhanced hepcidin expression have elevate body iron stores
High-Yield Explanation
Hepcidin, a 25-amino acid peptide secreted by hepatic Kupffer's cells downregulates duodenal iron absorption by regulating DMT1 activity as well as other proteins in the iron-responsive pathways (e.g., FP1). Hepcidin is a negative regulator of iron absorption because mice that fail to express hepcidin have elevated body iron stores, whereas mice with enhanced hepcidin expression have profound iron deficiency. .

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