Dental General b11fce43 The main cytokine, involved in erythema nodosum leprosum (ENL) reaction is – A Interleulcin – 2 B Interferon – gamma C Tumor necrosis factor – alpha D Macrophage colony stimulating factor High-Yield Explanation Most important cytokine for Type II lepra reaction (ENL) is tumor necrosis factor (TNF- α).