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Pharmacology General b1122a46

The gastrointestinal effects of metoclopramide does not include:

A
It accelerates gastric emptying
B
It alters colonic motility
C
It reduces reflex from the stomach into the oesophagus
D
It decreases the bioavailability of digoxin
High-Yield Explanation
Metoclopramide enhances the motility of the gut from the esophagus to the proximal small bowel with little effect on the colonic motility.  As the transit time is reduced bioavailability of drugs like digoxin is decreased. It accelerates gastric emptying, relaxes the upper stomach and increases antral contractions thus reducing reflux into the esophagus.

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