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Surgery General b0551251

Which among the following is not true about ankylosing spondylitis?

A
Enthesis is the primary site of pathology
B
More common in Females
C
TNF plays an impoant role in the pathogenesis of ankylosing spondylitis
D
Sacroiliitis is the earliest manifestation of ankylosing spondylitis
High-Yield Explanation
Ans.B. More common in FemalesAnkylosing spondylitis is more common in males.(M:F is between 2:1 to 3:1).There is preferential involvement of entheses ( Site of attachment of ligament or tendon to the bone).TNF a plays a major role in immunopathogenesis.Sacroiliitis is often the first manifestation of ankylosing spondylitis. Synovitis, pannus, subchondral granulation tissue and marrow edema, enthesitis and chondroid differentiation are also found.

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