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Pharmacology General b030fd28

Cardiomyopathy is a side effect caused by which of the following drug?

A
Adriamycin
B
Emetine
C
Paclitaxel
D
Vincristine
High-Yield Explanation
The anthracyclines doxorubicin and daunorubicin(anthracyclines) are well known causes of cardiomyopathy. It can occur many years after completion of therapy and the onset may be spontaneous or coincide with exeion or pregnancy. The incidence of cardiomyopathy is dose dependent and may exceed 30% among patients who received cumulative dose of anthracyclines in excess of 600mg/m2. Ref: Progress in Oncology 2002 edited by Vincent T. DeVita, page 174.

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