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Pharmacology C.V.S afb49818

Glyceryl trinitrate is given by sublingual route because of:

A
Short t1/2 in plasma
B
High hepatic first pass metabolism
C
High bioavailability by oral route
D
Extensive protein binding
High-Yield Explanation
Ans. (B) High hepatic first pass metabolism(Ref: KDT 8th/e p588)Main advantage of sublingual route of drug administration is that liver is bypassed and drugs with high first pass metabolism are absorbed directly into systemic circulation.

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