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Physiology All India exam af87a839

Which of the following clinical laboratory observations is suggestive of Hanup disease?

A
Burnt sugar smell in urine
B
High plasma phenylalanine levels
C
Extremely high levels of citrulline in urine
D
High fecal levels of tryptophan and indole derivatives
High-Yield Explanation
High fecal levels of tryptophan and indole derivatives Hanup disease is autosomal recessive metabolic disorder also known as pellagra like dermatosis. This affect the absorption of nonpolar( neutral ) amino acids specially tryptophan. So there is no absorption of tryptophan.

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