In Phenylketonuria the main aim of first-line therapy is
High-Yield Explanation
In PKU Phenylalanine hydroxylase enzyme is deficient.So alternative pathways are opened. Leading to the formation of Phenylketone,Phenyllactate and Phenylacetate. This can be prevented by limiting the substrate for deficient enzyme.Ref: DM Vasudevan - Textbook of Biochemistry, 7th edition, page no: 236