Development of diaphragmbegins at 4 weeks of gestation. Diaphragm has contributions from different structures. Central tendon of diaphragm develops from?

Development of Diaphragm Diaphragm develops from Septum transversum: it is a mass of mesodermal tissue arising from coelomic wall at the 4rd week of gestation. It forms the central tendon of diaphragm. Dorsal mesooesophagus forms the median portion of diaphragm & the crurae. Cervical myotomes (from C3-C5 somites) of lateral body wall form the peripheral parts of diaphragm. Pleuro-peritoneal membranes. Chromosome 15q plays a major role in diaphragm development - During the initial period of development, it lies at a higher level (cervical) and then migrates caudally and hence the nerve supply is from C3, C4, C5 (Phrenic nerve).