Full 2L QBank
Pediatrics Hemorrhagic and Thrombotic Diseases ae249705

A child with prolonged aPTT underwent laparotomy and still did not develop any bleeding complications. Which of the following clotting factors is most likely to be deficient?

A
Factor VII
B
Factor Xll
C
Factor X
D
Factor XIII
High-Yield Explanation
Ref: Nelson Textbook of Pediatrics, 18th editionExplanation:The dual mechanisms of activating clotting areA. Intrinsic - Surface activation -Measured by aPTTB. Extrinsic - Tissue factor mediated - Measured by PT* Deficiency of contact factors like Factor XII. prekallikrein & HMW Kininogen causes prolonged aPTT but no bleeding symptoms. (See the following table) Coagulation profile in common hematological conditionsDiseaseProthrombintime(PT)Partialthromboplastin lime (aPTT)BleedingtimePlateletcountBernard-Soulier syndromeUraffectedUnaffectedProlongedDecreased or unaffectedDisseminated intravascular coagulationProlongedProlongedProlongedDecreasedFactor XII deficiencyUnaffectedProlongedUnaffectedUnaffectedFactor V deficiencyProlongedProlongedUnaffectedUnaffectedFactor X deficiencyProlongedProlongedUnaffectedUnaffectedGlanzmann'sthrombastheniaUnaffectedUnaffectedProlongedUnaffectedHemophiliaUnaffectedProlongedUnaffectedUnaffectedLiver failure, earlyProlongedUnaffectedUnaffectedUnaffectedLiver failure end-stageProlongedProlongedProlongedDecreasedThrombocytopeniaUnaffectedUnaffectedProlongedDecreasedUremiaUnaffectedUnaffectedProlongedUnaffectedVitamin K deficiency or warfarin TherapyProlongedNormal or mildly prolongedUnaffectedUnaffectedVon Willebrand diseaseUnaffectedProlongedProlongedDecreased

Related Pediatrics MCQs

Practice 2,00,000+ NEET PG Questions Free

Timed mock tests, mistake queue analytics, audio lectures & zero attempt limits on i❤️Exams.

Start Free Mock Test Now