Dose of centchroman is ?

Ans. is 'a' i.e., 30 mg Cetchroman (Saheli) Ormeloxifene, research product of Central Drug Research Institute, Lucknow, India. It is a potent non - steroidal compound with potent anti - estrogenic and weak estrogenic propeies. It is taken orally (30 mg) twice a week for first three months then once a week. It works primarily by preventing implantation of feilized ovum. It does not inhibit ovulation. It is avoided in PCOD, with liver and kidney diseases and in tuberculosis. There may be a tendency of oligomenorrhoea. The failure rate is 1 - 4/100 woman years of use. Failure rate is less with increased doses. It is devoid of any significant adverse metabolic effect. This may also be used as a emergency contraceptive.