All of the following are true about Rheumatoid Ahritis, Except

Answer is A, B, C(PIP and DIP Joints involved Tally; Pathology Limited to aicular cailage; 20 percent have extra aicular manifestations) Women are affected 3 times more commonly than men Pathology is not limited to aicular cailage alone The majority of destruction occurs in juxtaposition to the inflamed synovium, or pannus, that spreads to cover the aicular cailage' The precise mechanism by which bone and cailage destruction occurs has not been completely resolved. Although the synol fluid contains a number of enzymes potentially able to degrade cailage, the majority of destruction occurs in juxtaposition to the inflamed synovium, or pannus, that spreads to cover the aicular cailage. The potential of the synol inflammation to cause cailage damage and bone erosions and subsequent changes in joint integtrity is the hallmark of the disease PIP and DIP Joints are not involved equally (DIP jolts are usually/typically spared) 'RA most often causes symmetric ahritis with characteristic involvement of ceain specific joints such as the proximal interphalangeal and metacarpophalangeal joints. The distal interphalangeal joints are rarely involved'. Extra aicular manifestations are seen in upto 40 percent of patients 'It is estimated that us many as 40% ofputients may have extraaicular manifestations, and in -15% these are severe' Rheumatoid nodules are seen in approximately 20% of patents Rheumotoid nodulels may develop in 20-30% of persons with RA'