Which one of the following drugs cause hypomagnesemia by increased excretion

Frusemide therapy "Loop diuretics cause the abolition of transepithelial potential difference that results in marked increase in excretion of Cc?'" and Me". Loop and thiazide diuretics cause significant urinary loss of magnesium. - Magnesium deficiency brought about by diuretics is rarely severe enough to induce the classic picture of neuromuscular irritability.