Which of the following is responsible for the inactive state of Phosphorylase b?
High-Yield Explanation
Insulin increases the uptake of glucose leading to the increased formation of glucose 6-phosphate which is an inhibitor of phosphorylase kinase, which in-turn is needed for the activation of Phosphorylase b. Ref: Lippincott's Biochemistry, 5th Edition, Pages 132, 133, 311 ; Harper's Textbook of Biochemistry, 27th Edition, Pages 161, 162, 163