Nigro protocol is for which carcinoma
High-Yield Explanation
Nigro protocol or Nigro Regime for Anal Carcinoma (Norman Nigro, et al 1974): * Initial radiotherapy for 3 weeks 3000 rads (30 Gy total) to perineum and pelvis * Then chemotherapy--5 FU, for 4-5 days; is a radiosensitizer, staed on 1st day of as 1000 mg/m2 continuous infusion. Mitomycin C is 15 mg/m2 as single dose on 1st day of * Later after 3 weeks abdominoperineal resection (APR) with colostomy in case of persistent or recurrent disease. Reference : page 987 SRB's manual of surgery 5th edition