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Biochemistry All India exam aa31eee7

Which of the following is known as suicidal enzyme?

A
Lipoxygenase
B
Cyclooxygenase
C
Thromboxane synthatase
D
5' nucleotidase
High-Yield Explanation
Suicidal enzyme is one, which undergoes self-destruction in order to terminate its own acitivity, e.g. Cyclooxygenase. Suicidal Inhibition is conversion of a substrate by the enzyme into a metabolite, which is a potent inhibitor of the enzyme; example: Xanthine oxidase conves allopurinol to alloxanthine (oxypurinol), which is a more potent inhibitor of allopurinol. Cycloorygenase is known as suicide enzyme because it catalyzes its own destruction. REF: Lippincott book of biochemistry 6th ed.

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